Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Thrombocytopenia Caused by Cytomegalovirus Infection In a Young Immunocompetent Woman

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ONLINE ISSN : 1349-7235
PRINT ISSN : 0918-2918


Internal Medicine
Vol. 43 (2004) , No. 12 pp.1177-1182

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Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Thrombocytopenia Caused by Cytomegalovirus Infection In a Young Immunocompetent Woman



Hiroe SATO1), Kyuzi KAMOI1), Takako SAEKI1), Hajime YAMAZAKI1), Tadashi KOIKE1), Syoji MIYAMURA1) and Fumitake GEJYO2)

1) Department of Internal Medicine, Nagaoka Red Cross Hospital
2) Department of Internal Medicine, Niigata University School of Medicine

(Received for publication March 12, 2004)
(Accepted for publication July 23, 2004)


Abstract
We report the first case of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with cytomegalovirus (CMV) infection. A 32-year-old woman was admitted to our hospital because of pandysautonomic signs and symptoms. Thrombocytopenia and hyponatremia were present. Serum anti-CMV IgM and IgG antibodies were positive. Despite hyponatremia, urinary osmolality exceeded plasma osmolality and plasma vasopressin levels related to plasma osmolality were high. Restriction of water intake and administration of dimethylchlorotetracycline improved hyponatremia, suggesting this patient had SIADH. In this patient, SIADH may have been caused by acute pandysautonomia that developed following CMV infection.

Key words: SIADH, hyponatremia, acute pandysautonomia, cytomegalovirus





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To cite this article:
Hiroe SATO; Kyuzi KAMOI; Takako SAEKI; Hajime YAMAZAKI; Tadashi KOIKE; Syoji MIYAMURA and Fumitake GEJYO, Syndrome of Inappropriate Secretion of Antidiuretic Hormone and Thrombocytopenia Caused by Cytomegalovirus Infection In a Young Immunocompetent Woman . Intern. Med. 43: 1177-1182, 2004 .

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doi:10.2169/internalmedicine.43.1177
JOI JST.JSTAGE/internalmedicine/43.1177

Copyright (c) 2005 by The Japanese Society of Internal Medicine


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