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dr Firman Abdullah SpOG / OBGYN

dr Firman Abdullah SpOG / OBGYN

Sunday, April 26, 2009

Hormonal treatments for adenomyosis

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1: Best Pract Res Clin Obstet Gynaecol. 2007 Aug 29; [Epub ahead of print] Links
Hormonal treatments for adenomyosis.Fedele L, Bianchi S, Frontino G.
Fondazione Policlinico, Mangiagalli e Regina Elena,Clinica Ostetrica e Ginecologica II, Università di Milano, Istituto Luigi Mangiagalli, Via della Commenda 12, 20122 Milano, Italy.

Like endometriosis and uterine myomas, adenomyosis presents the typical characteristics of oestrogen-dependent diseases. The medical treatment of adenomyosis is based on the hormonal dependency of the disease and its strongly debated similarities with endometriosis. Infact, despite the evident differences between the two conditions, the therapies that treat endometriosis effectively have also been successful for the treatment of adenomyosis. Although the two diseases have distinct epidemiological features, they have the same 'target tissue' for hormonal therapy, namely ectopic endometrium. Recognized approaches are systemic hormonal treatments, which are generally used for endometriosis and are capable of suppressing the oestrogenic induction of the disease, and local hormonal treatment that targets the ectopic endometrium directly. Gonadotropin-releasing hormone agonists, danazol and intrauterine levonorgestrel- or danazol-releasing devices have been used in the treatment of adenomyosis. Despite the solid rational basis for its hormonal treatment, few studies have been performed on medical therapy for adenomyosis.

PMID: 17765017 [PubMed - as supplied by publisher]

Related LinksAdenomyosis: the pathophysiology of an oestrogen-dependent disease. [Best Pract Res Clin Obstet Gynaecol. 2006] Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas. [Fertil Steril. 2003] Emerging drugs for endometriosis. [Expert Opin Emerg Drugs. 2004] Pharmacologic management of endometriosis. [Clin Pharm. 1991] Medical treatment of a grossly enlarged adenomyotic uterus with the levonorgestrel-releasing intrauterine system. [Contraception. 1999]See all Related Articles...
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drFirman Abdullah SpOG / ObGyn

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Dr Firman Abdullah SpOG/ OBGYN, Bukittinggi, Sumatera Barat ,Indonesia

Dr Firman Abdullah SpOG/ OBGYN,                              Bukittinggi, Sumatera Barat ,Indonesia

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