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Late-onset CMV disease following CMV prophylaxis
| Journal | Irish Journal of Medical Science |
| Publisher | Springer London |
| ISSN | 0021-1265 (Print) 1863-4362 (Online) |
| Issue | Volume 178, Number 3 / September, 2009 |
| Category | Brief Report |
| DOI | 10.1007/s11845-009-0327-3 |
| Pages | 333-336 |
| Subject Collection | Medicine |
| SpringerLink Date | Thursday, April 02, 2009 |
C. Donnelly1 
, F. Kennedy1 , C. Keane1, K. Schaffer2 and P. A. McCormick3
| (1) | Pharmacy Department, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland |
| (2) | Microbiology Department, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland |
| (3) | National Liver Transplant Unit, St. Vincent’s University Hospital and University College Dublin, Dublin 4, Ireland |
Received: 8 December 2008 Accepted: 9 March 2009 Published online: 2 April 2009
Abstract
Background Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplantation, increasing morbidity and mortality. Three months of oral valganciclovir have been shown to provide effective prophylaxis. Late-onset CMV disease, occurring after the discontinuation of prophylaxis, is now increasingly recognised.
Conclusions The incidence of CMV infections in this study was low compared with literature reports; however, the late-onset disease is an emerging problem. Detection of late-onset disease may be delayed because of less frequent clinic follow-up visits. Increased regular laboratory monitoring may allow earlier detection at the asymptomatic infection stage.
Keywords Cytomegalovirus - Liver transplant - Valganciclovir - Ganciclovir - Cytomegalovirus prophylaxis - Late-onset cytomegalovirus
This research was undertaken as part of an MSc in Hospital Pharmacy, awarded by Trinity College Dublin.
| C. Donnelly Email: c.donnelly@st-vincents.ie |
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