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Secondary cytomegalovirus infection can cause severe fetal sequelae despite maternal preconceptional immunity |
| Y. Zalel 1 *, Y. Gilboa 1, M. Berkenshtat 2, R. Yoeli 1, R. Auslander 3, R. Achiron 1, Y. Goldberg 3 |
| 1Ultrasound Unit, Department of Obstetrics & Gynecology, Sheba Medical Center, Tel-Hashomer (affiliated with the Sackler School of Medicine, Tel-Aviv University), Israel 2Genetic Institute, Sheba Medical Center, Tel-Hashomer (affiliated with the Sackler School of Medicine, Tel-Aviv University), Israel 3Ultrasound Unit, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa (affiliated with the Technion Institute of Technology, Faculty of Medicine, Haifa), Israel |
| email: Y. Zalel (zalel_y@netvision.net.il) |
*Correspondence to Y. Zalel, Department of Obstetrics & Gynecology, Sheba Medical Center, Tel-Hashomer, Ramat-Gan, 52621, Israel
| KEYWORDS |
| CMV • fetal infection • maternal immunity • ultrasonography |
| ABSTRACT |
Objectives |
To describe our experience in cases with sonographic signs of fetal infection and with maternal serological  immunity to cytomegalovirus (CMV) infection. |
Methods |
| This was a bicenter study of six pregnant women referred for evaluation of suspected fetal infection. All cases had confirmed maternal serology for past exposure to CMV but no evidence of recent secondary CMV infection. All underwent sonographic evaluation as well as complete investigation for CMV infection. |
Results |
| The mean age of the women was 29 (range, 23-35) years and the mean gestational age at diagnosis was 23.5 weeks (range, 20-31) weeks. Sonographic findings included microcephaly, ventriculomegaly, periventricular calcifications and cystic lesions, echogenic bowel, hydrops and hepatosplenomegaly. Amniocentesis was performed in all cases for fetal karyotyping and viral assessment, and all were found by polymerase chain reaction to be positive for CMV infection. Four pregnancies were terminated following the parents' request. One pregnancy continued until intrauterine fetal death occurred 2 weeks after diagnosis. Postmortem was denied in all cases but one. One infant was delivered with evidence of severe cerebral palsy. |
Conclusion |
| In the presence of sonographic findings suggestive of fetal CMV infection, prompt investigation of amniotic fluid should follow even if maternal serology does not support recent maternal seroconversion. Copyright © 2008 ISUOG. Published by John Wiley & Sons, Ltd. |
Accepted: 10 September 2007
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