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Q J Med 1988; 67: 425-430
© 1988 Association of Physicians
research-article |
Guillain-Barré Syndrome Associated with Cytomegalovirus Infection
From the Department of Neurology, Institute of Neurological Sciences, Southern General Hospital Glasgow G51 4TF
Address correspondence to Professor P. G. E. Kennedy PhD, MD, MRCP.
Accepted for publication 4 January 1988.
SUMMARY
Three cases of Guillain–Barré syndrome associated with serological evidence of active cyto-megalovirus (CMV) infection are described. There are a variety of problems in establishing a causal role for cytomegalovirus in the development of the Guillain-Barré syndrome, the most important of which relates to the unequivocal demonstration of a primary infection preceding the condition. It is postulated that an immune–mediated mechanism probably plays an important role in pathogenesis whether it is associated with cytomegalovirus or other human herpesviruses.
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