Cytomegalovirus as a frequent cause of Guillain-Barré syndrome

Article

Cytomegalovirus as a frequent cause of Guillain-Barré syndrome

H. Schmitz *, G. Enders

Virological Departments of the Centre for Hygiene, Freiburg and Med. Landesuntersuchungsamt, Stuttgart, Federal Republic of Germany

^*Correspondence to H. Schmitz, Virological Department of the Centre for Hygiene, Hermann Herder Str., D-7800 Freiburg, Federal Republic of Germany

KEYWORDS

cytomegalovirus • Guillain-Barré syndrome • IgM antibodies

ABSTRACT

In 10 patients with Guillain-Barré syndrome a preceeding cytomegalovirus infection could be demonstrated by virus-specific IgM antibodies that were present in high titers in 9 of the 10 patients in the first serum specimen. The IgM antibodies to cytomegalovirus were detected by a sensitive double indirect immunofluorescence technique. In most of our cases (8 of 10) the complement-fixing antibody titers had already reached high levels on admission into a hospital, and significant titer changes were not observed. Cytomegalovirus was isolated from the urine of five patients.

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Received: 13 September 1976

DIGITAL OBJECT IDENTIFIER (DOI)

10.1002/jmv.1890010105 About DOI

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